Cholesteatoma of middle ear

H8_CHOLEASTOMA

cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H71

Hospital discharge: ICD-9 3853

Hospital discharge: ICD-8 38700

Cause of death: ICD-10 H71

Cause of death: ICD-9 3853

Cause of death: ICD-8 38700

1215

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1215

Check minimum number of events None

1215

Include endpoints None

1215

H8_CHOLEASTOMA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H65-H75

Name in latin Cholesteatoma auris mediae

Similar endpoints

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List of similar endpoints to Cholesteatoma of middle ear based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1156	518	638
Unadjusted prevalence (%)	0.37	0.30	0.47
Mean age at first event (years)	46.98	45.44	48.23

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.29 [0.83, 2.02]	2.6e-1	147
15 years	0.01	0.94 [0.64, 1.40]	7.8e-1	69
5 years	0.00	1.27 [0.79, 2.02]	3.2e-1	24
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_CHOLEASTOMA – Cholesteatoma of middle ear
GWS hits: 0

Survival analyses between endpoints

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Plot

before Cholesteatoma of middle ear
after Cholesteatoma of middle ear

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Table

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Drugs most likely to be purchased after Cholesteatoma of middle ear

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