Cholesteatoma of middle ear


cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 H71
Hospital discharge: ICD-9 3853
Hospital discharge: ICD-8 38700
Cause of death: ICD-10 H71
Cause of death: ICD-9 3853
Cause of death: ICD-8 38700


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H65-H75
Name in latin Cholesteatoma auris mediae

Summary Statistics

Key figures

All Female Male
Number of individuals 1156 518 638
Unadjusted prevalence (%) 0.37 0.30 0.47
Mean age at first event (years) 46.98 45.44 48.23


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.29 [0.83, 2.02] 2.6e-1 147
15 years 0.01 0.94 [0.64, 1.40] 7.8e-1 69
5 years 0.00 1.27 [0.79, 2.02] 3.2e-1 24
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: H8_CHOLEASTOMA – Cholesteatoma of middle ear
GWS hits: 0

Survival analyses between endpoints


before Cholesteatoma of middle ear
after Cholesteatoma of middle ear

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Drugs most likely to be purchased after Cholesteatoma of middle ear