Disorders of lens


cataract: Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 H25-H28, H28.2*G71.11
Cause of death: ICD-10 H25-H28, H28.2*G71.11


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10


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Check minimum number of events None


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Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 46456 25113 21343
Unadjusted prevalence (%) 15.06 14.47 15.81
Mean age at first event (years) 69.92 69.66 70.24


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.24 [2.03, 2.47] 8.3e-60 8973
15 years 0.01 1.36 [1.24, 1.49] 3.7e-11 4520
5 years 0.00 2.31 [2.14, 2.49] <1e-100 3072
1 year 0.00 2.68 [2.37, 3.03] 1.9e-56 748

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: H7_LENS – Disorders of lens
GWS hits: 21

Survival analyses between endpoints


before Disorders of lens
after Disorders of lens

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Drugs most likely to be purchased after Disorders of lens