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Disorders of lens

DOIDEFOMESHSNOMED PheWeb

H7_LENS

cataract: Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 H25-H28, H28.2*G71.11
Cause of death: ICD-10 H25-H28, H28.2*G71.11

46900

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

46900

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Check minimum number of events None

46900

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Include endpoints

47967

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H7_LENS

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 46456 25113 21343
Unadjusted prevalence (%) 15.06 14.47 15.81
Mean age at first event (years) 69.92 69.66 70.24

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.24 [2.03, 2.47] 8.3e-60 8973
15 years 0.01 1.36 [1.24, 1.49] 3.7e-11 4520
5 years 0.00 2.31 [2.14, 2.49] <1e-100 3072
1 year 0.00 2.68 [2.37, 3.03] 1.9e-56 748

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_LENS – Disorders of lens
GWS hits: 21

Survival analyses between endpoints

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Plot

before Disorders of lens
after Disorders of lens

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Disorders of lens

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