Trigeminal neuralgia

G6_TRINEU

trigeminal neuralgia: Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theface), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G50.0

Hospital discharge: ICD-9 3501

Hospital discharge: ICD-8 35199

Cause of death: ICD-10 G50.0

Cause of death: ICD-9 3501

Cause of death: ICD-8 35199

KELA reimbursements: KELA codes 119

1257

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1257

Check minimum number of events None

1257

Include endpoints None

1257

G6_TRINEU

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G50

Name in latin Neuralgia trigeminalis

Similar endpoints

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List of similar endpoints to Trigeminal neuralgia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1203	846	357
Unadjusted prevalence (%)	0.39	0.49	0.26
Mean age at first event (years)	54.61	53.35	57.60

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.62 [0.91, 2.90]	1.0e-1	99
15 years	0.01	1.05 [0.63, 1.74]	8.5e-1	48
5 years	0.00	1.51 [0.86, 2.64]	1.5e-1	20
1 year	0.00	4.44 [2.22, 8.87]	2.5e-5	11

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_TRINEU – Trigeminal neuralgia
GWS hits: 0

Survival analyses between endpoints

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Plot

before Trigeminal neuralgia
after Trigeminal neuralgia

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Table

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Drugs most likely to be purchased after Trigeminal neuralgia

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