MS-disease / Multiple Sclerosis

G6_MS

multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G35

Hospital discharge: ICD-9 340

Hospital discharge: ICD-8 34099

Cause of death: ICD-10 G35

Cause of death: ICD-9 340

Cause of death: ICD-8 34099

KELA reimbursements: KELA codes 109

1768

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1758

Check minimum number of events None

1758

Include endpoints None

1758

G6_MS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G35-G37

Name in latin Sclerosis multiplex

Similar endpoints

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List of similar endpoints to MS-disease / Multiple Sclerosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1676	1274	402
Unadjusted prevalence (%)	0.54	0.73	0.30
Mean age at first event (years)	39.56	38.58	42.65

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.76 [0.31, 1.83]	5.3e-1	69
15 years	0.00	0.65 [0.28, 1.52]	3.2e-1	32
5 years	0.00	1.62 [0.74, 3.55]	2.3e-1	17
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_MS – MS-disease / Multiple Sclerosis
GWS hits: 1

Survival analyses between endpoints

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Plot

before MS-disease / Multiple Sclerosis
after MS-disease / Multiple Sclerosis

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Table

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Drugs most likely to be purchased after MS-disease / Multiple Sclerosis

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