MS-disease / Multiple Sclerosis


multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 G35
Hospital discharge: ICD-9 340
Hospital discharge: ICD-8 34099
Cause of death: ICD-10 G35
Cause of death: ICD-9 340
Cause of death: ICD-8 34099
KELA reimbursements: KELA codes 109


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G35-G37
Name in latin Sclerosis multiplex

Similar endpoints

List of similar endpoints to MS-disease / Multiple Sclerosis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 1676 1274 402
Unadjusted prevalence (%) 0.54 0.73 0.30
Mean age at first event (years) 39.56 38.58 42.65


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.76 [0.31, 1.83] 5.3e-1 69
15 years 0.00 0.65 [0.28, 1.52] 3.2e-1 32
5 years 0.00 1.62 [0.74, 3.55] 2.3e-1 17
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: G6_MS – MS-disease / Multiple Sclerosis
GWS hits: 1

Survival analyses between endpoints


before MS-disease / Multiple Sclerosis
after MS-disease / Multiple Sclerosis

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Drugs most likely to be purchased after MS-disease / Multiple Sclerosis