Thyrotoxicosis with toxic single thyroid nodule

E4_THYTOXNOD

Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E05.1

Hospital discharge: ICD-9 2421

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E05.1

Cause of death: ICD-9 2421

Cause of death: ICD-8 $!$

384

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

173

Check minimum number of events None

173

Include endpoints None

173

E4_THYTOXNOD

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E05

Name in latin Thyreotoxicosis cum struma uninodulari

Similar endpoints

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List of similar endpoints to Thyrotoxicosis with toxic single thyroid nodule based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	172	144	28
Unadjusted prevalence (%)	0.06	0.08	0.02
Mean age at first event (years)	51.67	49.16	64.56

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYTOXNOD – Thyrotoxicosis with toxic single thyroid nodule
GWS hits: 1

Survival analyses between endpoints

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Plot

before Thyrotoxicosis with toxic single thyroid nodule
after Thyrotoxicosis with toxic single thyroid nodule

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Table

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Drugs most likely to be purchased after Thyrotoxicosis with toxic single thyroid nodule

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