Thyrotoxicosis with toxic multinodular goitre

DOID EFO MESH SNOMED PheWeb

E4_THYTOXGOITMULT

Toxic Nodular Goiter: Nodular enlargement of the thyroid gland associated with hyperthyroidism.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E05.2

Hospital discharge: ICD-9 2422

Hospital discharge: ICD-8 2421

Cause of death: ICD-10 E05.2

Cause of death: ICD-9 2422

Cause of death: ICD-8 2421

1334

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1233

Check minimum number of events None

1233

Include endpoints None

1233

E4_THYTOXGOITMULT

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E05

Name in latin Thyreotoxicosis cum struma multinodulari

Similar endpoints

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List of similar endpoints to Thyrotoxicosis with toxic multinodular goitre based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1195	982	213
Unadjusted prevalence (%)	0.39	0.57	0.16
Mean age at first event (years)	57.28	56.33	61.65

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.87 [1.14, 3.06]	1.3e-2	110
15 years	0.01	1.05 [0.67, 1.66]	8.3e-1	44
5 years	0.00	1.88 [1.19, 2.98]	7.3e-3	25
1 year	0.00	4.05 [2.10, 7.82]	3.0e-5	11

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYTOXGOITMULT – Thyrotoxicosis with toxic multinodular goitre
GWS hits: 7

Survival analyses between endpoints

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Plot

before Thyrotoxicosis with toxic multinodular goitre
after Thyrotoxicosis with toxic multinodular goitre

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Table

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Drugs most likely to be purchased after Thyrotoxicosis with toxic multinodular goitre

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