Thalassaemia

D3_THALASSAEMIA

Thalassemia: An inherited blood disorder characterized by a decreased synthesis of one of the polypeptide chains that form hemoglobin. Anemia results from this abnormal hemoglobin formation.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D56

Cause of death: ICD-10 D56

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

Check minimum number of events None

Include endpoints

D3_ALPHATHALASSAEMIA

D3_BETATHALASSAEMIA

D3_DELTABETATHALASSAEMIA

D3_THALASSAEMIATRAIT

D3_HPFH

D3_THALASSAEMIANAS

D3_THALASSAEMIA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D55-D59

Name in latin Thalassaemia

Similar endpoints

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List of similar endpoints to Thalassaemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	36	19	17
Unadjusted prevalence (%)	0.01	0.01	0.01
Mean age at first event (years)	49.08	46.78	51.65

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_THALASSAEMIA – Thalassaemia
GWS hits:

Survival analyses between endpoints

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Plot

before Thalassaemia
after Thalassaemia

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Table

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Drugs most likely to be purchased after Thalassaemia

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