Hyperimmunoglobulin E [IgE] syndrome

D3_HYPERIGESDR

obsolete_Job's syndrome: ['Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D82.4

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 D82.4

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

D3_HYPERIGESDR

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D82

Name in latin Syndroma hyperimmunoglobulini E (IgE)

Similar endpoints

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List of similar endpoints to Hyperimmunoglobulin E [IgE] syndrome based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	12	8	-
Unadjusted prevalence (%)	0.00	0.00	-
Mean age at first event (years)	42.30	41.42	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_HYPERIGESDR – Hyperimmunoglobulin E [IgE] syndrome
GWS hits:

Survival analyses between endpoints

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Plot

before Hyperimmunoglobulin E [IgE] syndrome
after Hyperimmunoglobulin E [IgE] syndrome

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Table

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Drugs most likely to be purchased after Hyperimmunoglobulin E [IgE] syndrome

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