Hereditary factor VIII deficiency


obsolete_factor VIII deficiency: An X-linked disease that has_material_basis_in Factor VIII deficiency, which results in the formation of fibrin deficient clots which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 D66
Hospital discharge: ICD-9 2860
Hospital discharge: ICD-8 2860
Cause of death: ICD-10 D66
Cause of death: ICD-9 2860
Cause of death: ICD-8 2860


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D65-D69
Name in latin Deficientia hereditaria factoris VIII

Similar endpoints

List of similar endpoints to Hereditary factor VIII deficiency based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:


Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 63 23 40
Unadjusted prevalence (%) 0.02 0.01 0.03
Mean age at first event (years) 30.24 37.00 26.35


Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: D3_HEREDFVIIIDEF – Hereditary factor VIII deficiency
GWS hits:

Survival analyses between endpoints


before Hereditary factor VIII deficiency
after Hereditary factor VIII deficiency

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Drugs most likely to be purchased after Hereditary factor VIII deficiency