Cryoglobulinemia

D3_CRYOGLOBU

cryoglobulinemia: Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease ); and/or cancers of the blood or immune system . Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D89.1

Hospital discharge: ICD-9 2732A

Hospital discharge: ICD-8 2754

Cause of death: ICD-10 D89.1

Cause of death: ICD-9 2732A

Cause of death: ICD-8 2754

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

D3_CRYOGLOBU

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D89

Name in latin Cryoglobulinaemia

Similar endpoints

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List of similar endpoints to Cryoglobulinemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	24	13	11
Unadjusted prevalence (%)	0.01	0.01	0.01
Mean age at first event (years)	52.05	52.73	51.25

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_CRYOGLOBU – Cryoglobulinemia
GWS hits:

Survival analyses between endpoints

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Plot

before Cryoglobulinemia
after Cryoglobulinemia

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Table

Loading survival analyses table

Drugs most likely to be purchased after Cryoglobulinemia

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