Allergic purpura

D3_ALLERGPURPURA

Henoch-Schoenlein purpura: A systemic, usually self-limited immune complex vasculitis, characterized by immunoglobulin A deposition in the small vessels and kidneys. It is manifested with small hemorrhages in the skin, gastrointestinal symptoms, arthritis, and nephropathy.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D69.0

Hospital discharge: ICD-9 2870

Hospital discharge: ICD-8 2870

Cause of death: ICD-10 D69.0

Cause of death: ICD-9 2870

Cause of death: ICD-8 2870

715

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

715

Check minimum number of events None

715

Include endpoints None

715

D3_ALLERGPURPURA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D69

Name in latin Purpura allergica

Similar endpoints

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List of similar endpoints to Allergic purpura based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Henoch-Schönlein purpura nephritis (HSPN)

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

690

410

280

Unadjusted prevalence (%)

0.22

0.24

0.21

Mean age at first event (years)

39.07

36.82

42.36

?

Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.09	7.20 [3.22, 16.07]	1.5e-6	76
15 years	0.02	2.91 [1.52, 5.57]	1.3e-3	23
5 years	0.01	7.75 [4.38, 13.70]	1.9e-12	22
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ALLERGPURPURA – Allergic purpura
GWS hits: 0

Survival analyses between endpoints

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Plot

before Allergic purpura
after Allergic purpura

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Table

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Drugs most likely to be purchased after Allergic purpura

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