Allergic purpura

D3_ALLERGPURPURA

Henoch-Schoenlein purpura: A systemic, usually self-limited immune complex vasculitis, characterized by immunoglobulin A deposition in the small vessels and kidneys. It is manifested with small hemorrhages in the skin, gastrointestinal symptoms, arthritis, and nephropathy.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D69.0

Hospital discharge: ICD-9 2870

Hospital discharge: ICD-8 2870

Cause of death: ICD-10 D69.0

Cause of death: ICD-9 2870

Cause of death: ICD-8 2870

715

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

715

Check minimum number of events None

715

Include endpoints None

715

D3_ALLERGPURPURA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D69

Name in latin Purpura allergica

Similar endpoints

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List of similar endpoints to Allergic purpura based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Henoch-Schönlein purpura nephritis (HSPN)

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	690	410	280
Unadjusted prevalence (%)	0.22	0.24	0.21
Mean age at first event (years)	39.07	36.82	42.36

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.09	7.20 [3.22, 16.07]	1.5e-6	76
15 years	0.02	2.91 [1.52, 5.57]	1.3e-3	23
5 years	0.01	7.75 [4.38, 13.70]	1.9e-12	22
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ALLERGPURPURA – Allergic purpura
GWS hits: 0

Survival analyses between endpoints

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Plot

before Allergic purpura
after Allergic purpura

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Table

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Drugs most likely to be purchased after Allergic purpura

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