Carcinoma in situ of breast, other/unspecified

CD2_INSITU_BREAST_NOS

breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule

Sex only females

180574

Check conditions None

180574

Filter registries

Hospital Discharge: ICD-10 D05.7&, D05.9&

Hospital discharge: ICD-9 2330

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 D05.7&, D05.9&

Cause of death: ICD-9 2330

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

288

CD2_INSITU_BREAST_NOS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Carcinoma in situ of breast, other/unspecified based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	276	276	-
Unadjusted prevalence (%)	0.09	0.16	-
Mean age at first event (years)	58.08	58.08	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CD2_INSITU_BREAST_NOS – Carcinoma in situ of breast, other/unspecified
GWS hits: 0

Survival analyses between endpoints

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Plot

before Carcinoma in situ of breast, other/unspecified
after Carcinoma in situ of breast, other/unspecified

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Table

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Drugs most likely to be purchased after Carcinoma in situ of breast, other/unspecified

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