Malignant neoplasm of rectum

C3_RECTUM

rectum cancer: A primary or metastatic malignant neoplasm that affects the rectum. Representative examples include carcinoma, lymphoma, and sarcoma.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Cause of death: ICD-10 C20

Cause of death: ICD-9 154

Cause of death: ICD-8 1541

Cause of death: excluded ICD-9 1540|154[2-3]

Cancer registry: Topography ICD-O-3 C20

1896

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

1896

Check minimum number of events None

1896

Include endpoints None

1896

C3_RECTUM

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF4

Similar endpoints

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List of similar endpoints to Malignant neoplasm of rectum based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1832	689	1143
Unadjusted prevalence (%)	0.59	0.40	0.85
Mean age at first event (years)	66.48	64.81	67.48

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	4.26 [2.91, 6.24]	9.8e-14	427
15 years	0.01	1.28 [0.84, 1.94]	2.5e-1	117
5 years	0.00	3.50 [2.50, 4.91]	3.8e-13	142
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_RECTUM – Malignant neoplasm of rectum
GWS hits: 1

Survival analyses between endpoints

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Plot

before Malignant neoplasm of rectum
after Malignant neoplasm of rectum

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Table

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Drugs most likely to be purchased after Malignant neoplasm of rectum

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