Colon adenocarcinoma

C3_COLON_ADENO

colon adenocarcinoma: An adenocarcinoma arising from the colon. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, colonic adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

HLP_C3_COLON_ADENO

2385

Filter registries

Cause of death: ICD-10 C18

Cause of death: ICD-9 153

Cause of death: ICD-8 153

Cancer registry: Topography ICD-O-3 C18

Cancer registry: Morphology ICD-O-3 8140

Cancer registry: Behaviour codes 3

2385

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

2385

Check minimum number of events None

2385

Include endpoints None

2385

C3_COLON_ADENO

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF4

Similar endpoints

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List of similar endpoints to Colon adenocarcinoma based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2309	1006	1303
Unadjusted prevalence (%)	0.75	0.58	0.97
Mean age at first event (years)	67.69	66.30	68.77

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_COLON_ADENO – Colon adenocarcinoma
GWS hits: 3

Survival analyses between endpoints

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Plot

before Colon adenocarcinoma
after Colon adenocarcinoma

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Table

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Drugs most likely to be purchased after Colon adenocarcinoma

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