Allergic bronchopulmonary aspergillosis (ABPA)

ABPA

aspergillosis: Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma , a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess , is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 B44.1
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 B44.1
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

75

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

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ABPA

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 B44
Name in latin Aspergillosis pulmonalis

Summary Statistics

Key figures

All Female Male
Number of individuals 70 31 39
Unadjusted prevalence (%) 0.02 0.02 0.03
Mean age at first event (years) 62.65 59.39 65.24

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: ABPA – Allergic bronchopulmonary aspergillosis (ABPA)
GWS hits:

Survival analyses between endpoints

Plot

before Allergic bronchopulmonary aspergillosis (ABPA)
after Allergic bronchopulmonary aspergillosis (ABPA)

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Drugs most likely to be purchased after Allergic bronchopulmonary aspergillosis (ABPA)