Seropositive rheumatoid arthritis, wide

RHEUMA_SEROPOS_WIDE

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 M05
Hospital discharge: ICD-9 7140A|7141
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M05
Cause of death: ICD-9 7140A|7141
Cause of death: ICD-8 $!$

7478

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7473

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Check minimum number of events None

7473

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Include endpoints None

7473

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RHEUMA_SEROPOS_WIDE

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M05-M14
Name in latin Arthritis rheumatoides seropositiva

Summary Statistics

Key figures

All Female Male
Number of individuals 7290 5064 2226
Unadjusted prevalence (%) 2.36 2.92 1.65
Mean age at first event (years) 54.25 52.64 57.91

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.10 [1.74, 2.53] 9.6e-15 855
15 years 0.01 1.48 [1.24, 1.76] 1.0e-5 432
5 years 0.00 2.22 [1.86, 2.66] 2.5e-18 201
1 year 0.00 3.01 [2.22, 4.09] 1.3e-12 54

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: RHEUMA_SEROPOS_WIDE – Seropositive rheumatoid arthritis, wide
GWS hits: 24

Survival analyses between endpoints

Plot

before Seropositive rheumatoid arthritis, wide
after Seropositive rheumatoid arthritis, wide

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Drugs most likely to be purchased after Seropositive rheumatoid arthritis, wide