Degenerative macular diseases

MACULA_NAS

macular degeneration: Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [ NCIT:P378 ]

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H35.39#

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H35.39#

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

2707

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2707

Check minimum number of events None

2707

Include endpoints None

2707

MACULA_NAS

Extra metadata

Level in the ICD hierarchy 5

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H35

Name in latin Striae angioides maculae

Similar endpoints

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List of similar endpoints to Degenerative macular diseases based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Degenerative macular diseases, drug-induced

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2626	1435	1191
Unadjusted prevalence (%)	0.85	0.83	0.88
Mean age at first event (years)	66.35	65.52	67.36

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.66 [1.19, 2.32]	2.9e-3	357
15 years	0.01	1.03 [0.74, 1.43]	8.6e-1	199
5 years	0.00	1.80 [1.28, 2.52]	6.9e-4	113
1 year	0.00	2.26 [1.41, 3.61]	7.3e-4	26

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: MACULA_NAS – Degenerative macular diseases
GWS hits: 1

Survival analyses between endpoints

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Plot

before Degenerative macular diseases
after Degenerative macular diseases

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Table

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Drugs most likely to be purchased after Degenerative macular diseases

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