Rheumatic valve diseases

DOID EFO MESH SNOMED PheWeb

I9_RHEUVALV

tricuspid valve disease: A disease involving the tricuspid valve.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I05, I06, I07, I08

Hospital discharge: ICD-9 39[4-6]

Hospital discharge: ICD-8 3940|3950|3960|3970

Cause of death: ICD-10 I05, I06, I07, I08

Cause of death: ICD-9 39[4-6]

Cause of death: ICD-8 3940|3950|3960|3970

620

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

611

Check minimum number of events None

611

Include endpoints None

611

I9_RHEUVALV

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Rheumatic valve diseases based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	575	263	312
Unadjusted prevalence (%)	0.19	0.15	0.23
Mean age at first event (years)	53.35	51.65	54.78

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.28 [1.35, 3.84]	2.0e-3	221
15 years	0.01	1.28 [0.83, 1.99]	2.6e-1	89
5 years	0.00	1.99 [1.35, 2.94]	5.3e-4	41
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_RHEUVALV – Rheumatic valve diseases
GWS hits: 1

Survival analyses between endpoints

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Plot

before Rheumatic valve diseases
after Rheumatic valve diseases

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Rheumatic valve diseases

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