Myasthenia gravis

G6_MYASTHENIA

Myasthenia gravis: Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G70.0#

Hospital discharge: ICD-9 3580

Hospital discharge: ICD-8 7330

Cause of death: ICD-10 G70.0#

Cause of death: ICD-9 3580

Cause of death: ICD-8 7330

KELA reimbursements: KELA codes 108

418

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

338

Check minimum number of events None

338

Include endpoints None

338

G6_MYASTHENIA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G70

Similar endpoints

↥

List of similar endpoints to Myasthenia gravis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Myasthenia gravis, drug-induced

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	329	186	143
Unadjusted prevalence (%)	0.11	0.11	0.11
Mean age at first event (years)	52.23	47.30	58.64

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.50 [0.69, 3.28]	3.1e-1	33
15 years	0.00	0.70 [0.29, 1.68]	4.2e-1	13
5 years	0.00	2.01 [0.82, 4.92]	1.3e-1	10
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: G6_MYASTHENIA – Myasthenia gravis
GWS hits: 0

Survival analyses between endpoints

↥

Plot

before Myasthenia gravis
after Myasthenia gravis

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Myasthenia gravis

↥