Diabethic neuropathy

G6_DIABETNEUR

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G590|E104|E114|E124|E134|E144

Hospital discharge: ICD-9 2505

Hospital discharge: ICD-8 25005

Cause of death: ICD-10 G590|E104|E114|E124|E134|E144

Cause of death: ICD-9 2505

Cause of death: ICD-8 25005

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

2266

G6_DIABETNEUR

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Diabethic neuropathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2213	822	1391
Unadjusted prevalence (%)	0.72	0.47	1.03
Mean age at first event (years)	56.23	53.85	57.64

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.07	5.68 [4.62, 6.98]	5.2e-61	578
15 years	0.02	2.83 [2.30, 3.49]	1.4e-22	254
5 years	0.01	4.60 [3.70, 5.72]	1.1e-42	169
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_DIABETNEUR – Diabethic neuropathy
GWS hits: 1

Survival analyses between endpoints

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Plot

before Diabethic neuropathy
after Diabethic neuropathy

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Table

Loading survival analyses table

Drugs most likely to be purchased after Diabethic neuropathy

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