Sickle-cell disorders

D3_SICKLECELLDIS

obsolete_sickle cell disease: ['A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia.']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D57

Hospital discharge: ICD-9 282[5-6]

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 D57

Cause of death: ICD-9 282[5-6]

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

D3_SICKLECELLDIS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D55-D59

Name in latin Morbi meniscocytici

Similar endpoints

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List of similar endpoints to Sickle-cell disorders based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	47	25	22
Unadjusted prevalence (%)	0.02	0.01	0.02
Mean age at first event (years)	57.55	57.91	57.15

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_SICKLECELLDIS – Sickle-cell disorders
GWS hits:

Survival analyses between endpoints

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Plot

before Sickle-cell disorders
after Sickle-cell disorders

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Sickle-cell disorders

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