Idiopathic thrombocytopenic purpura

D3_ITP

autoimmune thrombocytopenic purpura: An autoimmune disorder in which the number of circulating platelets is reduced due to their antibody-mediated destruction. ITP is a diagnosis of exclusion and is heterogeneous in origin.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D69.3

Hospital discharge: ICD-9 2873A

Hospital discharge: ICD-8 28710

Cause of death: ICD-10 D69.3

Cause of death: ICD-9 2873A

Cause of death: ICD-8 28710

630

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

630

Check minimum number of events None

630

Include endpoints None

630

D3_ITP

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D69

Name in latin Purpura idiopathica thrombocytopenica

Similar endpoints

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List of similar endpoints to Idiopathic thrombocytopenic purpura based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	605	328	277
Unadjusted prevalence (%)	0.20	0.19	0.21
Mean age at first event (years)	48.07	43.42	53.58

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.10 [1.80, 5.36]	5.0e-5	80
15 years	0.01	1.24 [0.67, 2.30]	4.9e-1	27
5 years	0.00	2.51 [1.33, 4.72]	4.5e-3	18
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ITP – Idiopathic thrombocytopenic purpura
GWS hits: 0

Survival analyses between endpoints

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Plot

before Idiopathic thrombocytopenic purpura
after Idiopathic thrombocytopenic purpura

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Table

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Drugs most likely to be purchased after Idiopathic thrombocytopenic purpura

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