Functional disorders of polymorphonuclear neutrophils

D3_FUNCPOLYMORPHONUCNEUTRO

obsolete_chronic granulomatous disease: ['A recessive X-linked defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation.']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D71

Hospital discharge: ICD-9 2881

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 D71

Cause of death: ICD-9 2881

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

D3_FUNCPOLYMORPHONUCNEUTRO

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D70-D77

Name in latin Dysfunctiones granulocytorum neutrophilorum segmentonuclearium

Similar endpoints

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List of similar endpoints to Functional disorders of polymorphonuclear neutrophils based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

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Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	17	10	7
Unadjusted prevalence (%)	0.01	0.01	0.01
Mean age at first event (years)	41.17	43.67	37.60

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_FUNCPOLYMORPHONUCNEUTRO – Functional disorders of polymorphonuclear neutrophils
GWS hits:

Survival analyses between endpoints

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Plot

before Functional disorders of polymorphonuclear neutrophils
after Functional disorders of polymorphonuclear neutrophils

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Drugs most likely to be purchased after Functional disorders of polymorphonuclear neutrophils

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