Anaemia due to enzyme disorders

D3_ANAEMIAENZYME

congenital nonspherocytic hemolytic anemia: Any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there is a defect of glycolysis in the erythrocyte. In some cases, pyruvate kinase deficiency has been demonstrated; in other cases, glucose-6-phosphate dehydrogenase deficiency has been demonstrated.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D55

Hospital discharge: ICD-9 282[2-3]

Hospital discharge: ICD-8 282[2-3]

Cause of death: ICD-10 D55

Cause of death: ICD-9 282[2-3]

Cause of death: ICD-8 282[2-3]

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

D3_ANAEMIAENZYME

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D55-D59

Name in latin Anaemiae ex perturbationibus enzymaticis

Similar endpoints

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List of similar endpoints to Anaemia due to enzyme disorders based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	22	14	8
Unadjusted prevalence (%)	0.01	0.01	0.01
Mean age at first event (years)	41.35	37.95	47.30

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ANAEMIAENZYME – Anaemia due to enzyme disorders
GWS hits:

Survival analyses between endpoints

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Plot

before Anaemia due to enzyme disorders
after Anaemia due to enzyme disorders

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Table

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Drugs most likely to be purchased after Anaemia due to enzyme disorders

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