Other/unspecified rheumatoid arthritis

RHEUMA_NOS

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M06.8, M06.9

Hospital discharge: ICD-9 7148

Hospital discharge: ICD-8 7123[8-9]

Cause of death: ICD-10 M06.8, M06.9

Cause of death: ICD-9 7148

Cause of death: ICD-8 7123[8-9]

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

3152

RHEUMA_NOS

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other/unspecified rheumatoid arthritis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3076	2112	964
Unadjusted prevalence (%)	1.00	1.22	0.71
Mean age at first event (years)	49.42	47.81	52.97

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.26 [1.54, 3.30]	2.7e-5	521
15 years	0.01	1.35 [0.99, 1.84]	5.9e-2	209
5 years	0.00	3.15 [2.44, 4.06]	7.1e-19	147
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_NOS – Other/unspecified rheumatoid arthritis
GWS hits: 4

Survival analyses between endpoints

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Plot

before Other/unspecified rheumatoid arthritis
after Other/unspecified rheumatoid arthritis

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Other/unspecified rheumatoid arthritis

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