Fasciculation

R18_FASCICULATION

persistent fetal circulation syndrome: A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 R25.3
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 R25.3
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

210

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

210

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Check minimum number of events None

210

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Include endpoints None

210

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R18_FASCICULATION

Extra metadata

Level in the ICD hierarchy 4
Special FASCICULATION
First used in FinnGen datafreeze DF4
Parent code in ICD-10 R25
Name in latin Fasciculationes

Summary Statistics

Key figures

All Female Male
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Number of individuals
207 111 96
?
Unadjusted prevalence (%)
0.07 0.06 0.07
?
Mean age at first event (years)
49.57 44.62 55.28

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Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: R18_FASCICULATION – Fasciculation
GWS hits: 0

Survival analyses between endpoints

Plot

before Fasciculation
after Fasciculation

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