Polycythaemia vera

POLYCYTVERA

chronic myeloproliferative disorder: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D45

Hospital discharge: ICD-9 2384

Hospital discharge: ICD-8 208

Cause of death: ICD-10 D45

Cause of death: ICD-9 2384

Cause of death: ICD-8 208

712

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

696

Check minimum number of events None

696

Include endpoints None

696

POLYCYTVERA

Extra metadata

First used in FinnGen datafreeze DF2, additional

Similar endpoints

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List of similar endpoints to Polycythaemia vera based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	680	333	347
Unadjusted prevalence (%)	0.22	0.19	0.26
Mean age at first event (years)	62.48	62.57	62.39

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	4.24 [2.80, 6.43]	9.9e-12	129
15 years	0.02	2.55 [1.74, 3.72]	1.4e-6	68
5 years	0.00	3.19 [2.03, 5.01]	5.1e-7	36
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: POLYCYTVERA – Polycythaemia vera
GWS hits: 8

Survival analyses between endpoints

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Plot

before Polycythaemia vera
after Polycythaemia vera

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Table

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Drugs most likely to be purchased after Polycythaemia vera

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