Nephrotic syndrome

N14_NEPHROTICSYND

nephrotic syndrome: A collection of symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 N04#

Hospital discharge: ICD-9 581

Hospital discharge: ICD-8 581

Cause of death: ICD-10 N04#

Cause of death: ICD-9 581

Cause of death: ICD-8 581

713

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

713

Check minimum number of events None

713

Include endpoints None

713

N14_NEPHROTICSYND

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 N00-N08

Name in latin Syndroma nephroticum

Similar endpoints

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List of similar endpoints to Nephrotic syndrome based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	679	281	398
Unadjusted prevalence (%)	0.22	0.16	0.29
Mean age at first event (years)	43.67	39.73	46.46

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.45 [1.75, 6.79]	3.4e-4	99
15 years	0.01	1.37 [0.64, 2.93]	4.2e-1	36
5 years	0.01	4.71 [2.26, 9.81]	3.6e-5	41
1 year	0.00	8.03 [3.53, 18.27]	7.0e-7	13

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: N14_NEPHROTICSYND – Nephrotic syndrome
GWS hits: 1

Survival analyses between endpoints

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Plot

before Nephrotic syndrome
after Nephrotic syndrome

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Table

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Drugs most likely to be purchased after Nephrotic syndrome

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