Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

N14_DRUGSANDHEAVYMETAL

acute kidney tubular necrosis: Acute renal failure caused by the cell death of the renal tubules. Causes include nephrotoxins, cytotoxic drugs, and antibiotics.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 N14

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 N14

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

N14_DRUGSANDHEAVYMETAL

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 N10-N16

Name in latin Condiciones tubulo-interstitiales et tubulares ex medicamentis et metallis gravibus

Similar endpoints

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List of similar endpoints to Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	67	25	42
Unadjusted prevalence (%)	0.02	0.01	0.03
Mean age at first event (years)	53.75	54.45	53.33

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: N14_DRUGSANDHEAVYMETAL – Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
GWS hits:

Survival analyses between endpoints

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Plot

before Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
after Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

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Table

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Drugs most likely to be purchased after Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

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