Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

N14_DRUGSANDHEAVYMETAL

acute kidney tubular necrosis: Acute renal failure caused by the cell death of the renal tubules. Causes include nephrotoxins, cytotoxic drugs, and antibiotics.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 N14
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 N14
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

69

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

69

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Check minimum number of events None

69

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Include endpoints None

69

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N14_DRUGSANDHEAVYMETAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N10-N16
Name in latin Condiciones tubulo-interstitiales et tubulares ex medicamentis et metallis gravibus

Similar endpoints

List of similar endpoints to Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 67 25 42
Unadjusted prevalence (%) 0.02 0.01 0.03
Mean age at first event (years) 53.75 54.45 53.33

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: N14_DRUGSANDHEAVYMETAL – Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
GWS hits:

Survival analyses between endpoints

Plot

before Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
after Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

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Drugs most likely to be purchased after Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions