Myelofibrosis

MYELOFIBROSIS

primary myelofibrosis: Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.

Endpoint definition

FinnGen phenotype data

321302 individuals

diagram downward connector

Apply sex-specific rule None

321302

diagram downward connector

Check conditions None

321302

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 C94.5
Hospital discharge: ICD-9 2387A
Hospital discharge: ICD-8 209
Cause of death: ICD-10 C94.5
Cause of death: ICD-9 2387A
Cause of death: ICD-8 209

15

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

15

diagram downward connector

Check minimum number of events None

15

diagram downward connector

Include endpoints None

15

diagram downward connector
MYELOFIBROSIS

Extra metadata

First used in FinnGen datafreeze DF2, additional

Summary Statistics

Key figures

All Female Male
Number of individuals 15 5 10
Unadjusted prevalence (%) 0.00 0.00 0.01
Mean age at first event (years) 47.61 32.65 55.09

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: MYELOFIBROSIS – Myelofibrosis
GWS hits:

Survival analyses between endpoints

Plot

before Myelofibrosis
after Myelofibrosis

loading spinner Loading survival analyses plot