Other disorders of the musculoskeletal system and connective tissue

M13_MUSCULOSKELEOTH

musculoskeletal system disease: A disease involving the musculoskeletal system. [database_cross_reference: MONDO:DesignPattern]

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 M95-M99
Cause of death: ICD-10 M95-M99

2110

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

2110

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Check minimum number of events None

2110

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M13_MUSCULOSKELEOTH

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Other disorders of the musculoskeletal system and connective tissue based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

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Summary Statistics

Key figures

All Female Male
Number of individuals 3007 1677 1330
Unadjusted prevalence (%) 0.97 0.97 0.99
Mean age at first event (years) 49.41 48.49 50.57

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.81 [1.02, 3.23] 4.4e-2 261
15 years 0.01 1.14 [0.72, 1.81] 5.8e-1 107
5 years 0.00 2.45 [1.66, 3.63] 7.3e-6 64
1 year 0.00 3.62 [2.10, 6.23] 3.4e-6 18

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_MUSCULOSKELEOTH – Other disorders of the musculoskeletal system and connective tissue
GWS hits: 0

Survival analyses between endpoints

Plot

before Other disorders of the musculoskeletal system and connective tissue
after Other disorders of the musculoskeletal system and connective tissue

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Drugs most likely to be purchased after Other disorders of the musculoskeletal system and connective tissue