Other specified/unspecified hearing loss

H8_HL_NAS

sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H91.8, H91.9

Hospital discharge: ICD-9 389[8-9]

Hospital discharge: ICD-8 389

Cause of death: ICD-10 H91.8, H91.9

Cause of death: ICD-9 389[8-9]

Cause of death: ICD-8 389

1884

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1670

Check minimum number of events None

1670

Include endpoints None

1670

H8_HL_NAS

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other specified/unspecified hearing loss based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1604	769	835
Unadjusted prevalence (%)	0.52	0.44	0.62
Mean age at first event (years)	59.40	55.48	63.01

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.40 [1.44, 4.01]	7.7e-4	237
15 years	0.01	0.96 [0.57, 1.63]	8.9e-1	82
5 years	0.00	3.34 [2.36, 4.73]	9.4e-12	108
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_HL_NAS – Other specified/unspecified hearing loss
GWS hits: 0

Survival analyses between endpoints

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Plot

before Other specified/unspecified hearing loss
after Other specified/unspecified hearing loss

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Other specified/unspecified hearing loss

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