Retrobulbar neuritis in diseases classified elsewhere

H7_RETROBULBNEURINOTH

optic neuritis: Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis , drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H48.1*, H48.1*A39.8, H48.1*A52.1, H48.1*A69.2, H48.1*G35

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H48.1*, H48.1*A39.8, H48.1*A52.1, H48.1*A69.2, H48.1*G35

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

H7_RETROBULBNEURINOTH

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Retrobulbar neuritis in diseases classified elsewhere based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	71	55	16
Unadjusted prevalence (%)	0.02	0.03	0.01
Mean age at first event (years)	42.89	41.88	46.35

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_RETROBULBNEURINOTH – Retrobulbar neuritis in diseases classified elsewhere
GWS hits:

Survival analyses between endpoints

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Plot

before Retrobulbar neuritis in diseases classified elsewhere
after Retrobulbar neuritis in diseases classified elsewhere

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Table

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Drugs most likely to be purchased after Retrobulbar neuritis in diseases classified elsewhere

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