Retinopathy of prematurity


retinopathy of prematurity: A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)

Endpoint definition

FinnGen phenotype data

321302 individuals

diagram downward connector

Apply sex-specific rule None


diagram downward connector

Check conditions None


diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 H35.1
Hospital discharge: ICD-9 3622A
Hospital discharge: ICD-8 37704
Cause of death: ICD-10 H35.1
Cause of death: ICD-9 3622A
Cause of death: ICD-8 37704


diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


diagram downward connector

Check minimum number of events None


diagram downward connector

Include endpoints None


diagram downward connector

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35
Name in latin Retinopathia praematuritatis

Summary Statistics

Key figures

All Female Male
Number of individuals 70 42 28
Unadjusted prevalence (%) 0.02 0.02 0.02
Mean age at first event (years) 36.12 40.29 29.86


Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: H7_RETINOPATPREMAT – Retinopathy of prematurity
GWS hits:

Survival analyses between endpoints


before Retinopathy of prematurity
after Retinopathy of prematurity

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Retinopathy of prematurity