Optic neuritis

H7_OPTNEURITIS

optic neuritis: Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis , drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 H46
Hospital discharge: ICD-9 3773
Hospital discharge: ICD-8 3670[2-9]
Cause of death: ICD-10 H46
Cause of death: ICD-9 3773
Cause of death: ICD-8 3670[2-9]

998

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

989

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Check minimum number of events None

989

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Include endpoints None

989

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H7_OPTNEURITIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H46-H48
Name in latin Neuritis optica

Summary Statistics

Key figures

All Female Male
Number of individuals 951 707 244
Unadjusted prevalence (%) 0.31 0.41 0.18
Mean age at first event (years) 39.00 37.79 42.49

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 3.43 [1.99, 5.92] 8.9e-6 47
15 years 0.01 1.95 [1.04, 3.65] 3.6e-2 19
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_OPTNEURITIS – Optic neuritis
GWS hits: 1

Survival analyses between endpoints

Plot

before Optic neuritis
after Optic neuritis

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