Primary open-angle glaucoma, strict

H7_GLAUCOMA_POAG

open-angle glaucoma: Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H40.1

Hospital discharge: ICD-9 3651[A|C|E|X]

Hospital discharge: ICD-8 37510

Hospital discharge: excluded ICD-10 H40.10, H40.12

Cause of death: ICD-10 H40.1

Cause of death: ICD-9 3651[A|C|E|X]

Cause of death: ICD-8 37510

Cause of death: excluded ICD-10 H40.10, H40.12

5690

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5690

Check minimum number of events None

5690

Include endpoints None

5690

H7_GLAUCOMA_POAG

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF4

Parent code in ICD-10 H40

Name in latin Glaucoma simplex primarium

Similar endpoints

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List of similar endpoints to Primary open-angle glaucoma, strict based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	5517	3057	2460
Unadjusted prevalence (%)	1.79	1.76	1.82
Mean age at first event (years)	67.17	66.88	67.52

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.66 [1.39, 1.98]	2.9e-8	799
15 years	0.01	1.04 [0.87, 1.23]	6.9e-1	426
5 years	0.00	1.27 [1.05, 1.55]	1.5e-2	206
1 year	0.00	1.99 [1.48, 2.67]	4.3e-6	61

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_GLAUCOMA_POAG – Primary open-angle glaucoma, strict
GWS hits: 15

Survival analyses between endpoints

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Plot

before Primary open-angle glaucoma, strict
after Primary open-angle glaucoma, strict

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Table

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Drugs most likely to be purchased after Primary open-angle glaucoma, strict

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