Falls/tendency to fall

FALLS

vestibular disease: Pathological processes of the vestibular labyrinth which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls. [database_cross_reference: MESH:D015837]

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 R29.6, W00-W19

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 R29.6, W00-W19

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

1482

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1482

Check minimum number of events None

1482

Include endpoints None

1482

FALLS

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Falls/tendency to fall based on the number of shared cases.

Broader endpoints:

Any ICDMAIN event in hilmo or causes of death

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1435	551	884
Unadjusted prevalence (%)	0.47	0.32	0.65
Mean age at first event (years)	71.74	71.15	72.11

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.26	22.47 [10.45, 48.33]	1.6e-15	1029
15 years	0.01	1.01 [0.46, 2.20]	9.9e-1	25
5 years	0.00	3.09 [1.73, 5.51]	1.4e-4	26
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: FALLS – Falls/tendency to fall
GWS hits: 0

Survival analyses between endpoints

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Plot

before Falls/tendency to fall
after Falls/tendency to fall

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Falls/tendency to fall

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