Depression

F5_DEPRESSIO

unipolar depression: A mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F32, F33

Hospital discharge: ICD-9 2961|2968|3004

Hospital discharge: ICD-8 79020|2980

Cause of death: ICD-10 F32, F33

Cause of death: ICD-9 2961|2968|3004

Cause of death: ICD-8 79020|2980

36321

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

35121

Check minimum number of events None

35121

Include endpoints None

35121

F5_DEPRESSIO

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF6

Similar endpoints

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List of similar endpoints to Depression based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	33812	22543	11269
Unadjusted prevalence (%)	10.96	12.99	8.35
Mean age at first event (years)	41.61	40.38	44.08

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.85 [2.51, 3.24]	1.7e-57	2069
15 years	0.01	1.81 [1.60, 2.05]	6.0e-21	933
5 years	0.00	3.11 [2.73, 3.54]	4.0e-67	501
1 year	0.00	8.47 [7.17, 10.00]	<1e-100	270

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_DEPRESSIO – Depression
GWS hits: 4

Survival analyses between endpoints

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Plot

before Depression
after Depression

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Table

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Drugs most likely to be purchased after Depression

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