AION (anterior ischemic optic neuropathy)

DOID MESH PheWeb

DM_AION

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H47.0

Hospital discharge: ICD-9 3774

Hospital discharge: ICD-8 37799

Cause of death: ICD-10 H47.0

Cause of death: ICD-9 3774

Cause of death: ICD-8 37799

394

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

394

Check minimum number of events None

394

Include endpoints None

394

DM_AION

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H47

Name in latin Morbositates nervi optici non alibi classificatae

Similar endpoints

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List of similar endpoints to AION (anterior ischemic optic neuropathy) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Disorders of optic nerve, not elsewhere classified

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	384	202	182
Unadjusted prevalence (%)	0.12	0.12	0.13
Mean age at first event (years)	58.73	56.52	61.18

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.07 [0.98, 4.37]	5.7e-2	43
15 years	0.01	1.13 [0.55, 2.30]	7.4e-1	17
5 years	0.00	2.19 [1.09, 4.36]	2.7e-2	10
1 year	0.00	13.25 [6.63, 26.48]	2.6e-13	12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_AION – AION (anterior ischemic optic neuropathy)
GWS hits: 0

Survival analyses between endpoints

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Plot

before AION (anterior ischemic optic neuropathy)
after AION (anterior ischemic optic neuropathy)

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Table

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Drugs most likely to be purchased after AION (anterior ischemic optic neuropathy)

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