Sarcoidosis

D3_SARCOIDOSIS

obsolete_sarcoidosis: ['An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin.', 'An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D86

Hospital discharge: ICD-9 135

Hospital discharge: ICD-8 135

Cause of death: ICD-10 D86

Cause of death: ICD-9 135

Cause of death: ICD-8 135

KELA reimbursements: KELA codes 132

3185

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3185

Check minimum number of events None

3185

Include endpoints None

3185

D3_SARCOIDOSIS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D80-D89

Name in latin Sarcoidosis

Similar endpoints

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List of similar endpoints to Sarcoidosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3103	1734	1369
Unadjusted prevalence (%)	1.01	1.00	1.01
Mean age at first event (years)	46.63	47.39	45.66

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.04 [1.41, 2.97]	1.8e-4	222
15 years	0.01	1.30 [0.91, 1.85]	1.5e-1	92
5 years	0.00	2.13 [1.46, 3.12]	9.5e-5	38
1 year	0.00	7.11 [4.50, 11.23]	4.4e-17	24

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_SARCOIDOSIS – Sarcoidosis
GWS hits: 9

Survival analyses between endpoints

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Plot

before Sarcoidosis
after Sarcoidosis

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Table

Loading survival analyses table

Drugs most likely to be purchased after Sarcoidosis

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