Vitamin B12 deficiency anaemia

DOID EFO MESH SNOMED PheWeb

D3_ANAEMIA_B12_DEF

vitamin B12 deficiency: A disease characterized by low serum levels of vitamin B12, either inherited or acquired.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D51

Hospital discharge: ICD-9 281[0-1]

Hospital discharge: ICD-8 281[0-1]

Cause of death: ICD-10 D51

Cause of death: ICD-9 281[0-1]

Cause of death: ICD-8 281[0-1]

KELA reimbursements: KELA codes 107

2635

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2635

Check minimum number of events None

2635

Include endpoints None

2635

D3_ANAEMIA_B12_DEF

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D50-D53

Name in latin Anaemia ex deficientia vitamini B12

Similar endpoints

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List of similar endpoints to Vitamin B12 deficiency anaemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2542	1373	1169
Unadjusted prevalence (%)	0.82	0.79	0.87
Mean age at first event (years)	59.80	56.49	63.69

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.18 [1.60, 2.97]	8.5e-7	516
15 years	0.01	1.15 [0.88, 1.51]	3.0e-1	208
5 years	0.00	2.52 [1.98, 3.20]	5.6e-14	148
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ANAEMIA_B12_DEF – Vitamin B12 deficiency anaemia
GWS hits: 6

Survival analyses between endpoints

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Plot

before Vitamin B12 deficiency anaemia
after Vitamin B12 deficiency anaemia

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Table

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Drugs most likely to be purchased after Vitamin B12 deficiency anaemia

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