Later onset COPD

COPD_LATER

chronic obstructive pulmonary disease: A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not COPD_EARLY

315534

Filter registries

Hospital Discharge: ICD-10 J44

Hospital discharge: ICD-9 4912

Hospital discharge: ICD-8 49104

Cause of death: ICD-10 J44

Cause of death: ICD-9 4912

Cause of death: ICD-8 49104

7288

Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE>=65

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7288

Check minimum number of events None

7288

Include endpoints None

7288

COPD_LATER

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 J40-J47

Name in latin Alii morbi obstructivi chronici pulmonum

Similar endpoints

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List of similar endpoints to Later onset COPD based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	7094	1404	5690
Unadjusted prevalence (%)	2.30	0.81	4.21
Mean age at first event (years)	73.68	72.72	73.92

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.08	6.01 [4.83, 7.47]	1.8e-58	3705
15 years	0.01	2.31 [1.96, 2.73]	3.0e-23	1168
5 years	0.01	5.52 [4.92, 6.19]	<1e-100	1388
1 year	0.00	17.41 [15.33, 19.77]	<1e-100	1081

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: COPD_LATER – Later onset COPD
GWS hits: 2

Survival analyses between endpoints

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Plot

before Later onset COPD
after Later onset COPD

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Table

Loading survival analyses table

Drugs most likely to be purchased after Later onset COPD

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