Early onset COPD

COPD_EARLY

chronic obstructive pulmonary disease: A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.

Endpoint definition

FinnGen phenotype data

321302 individuals

diagram downward connector

Apply sex-specific rule None

321302

diagram downward connector

Check conditions None

321302

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 J44
Hospital discharge: ICD-9 4912
Hospital discharge: ICD-8 49104
Cause of death: ICD-10 J44
Cause of death: ICD-9 4912
Cause of death: ICD-8 49104

13056

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE<65
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5768

diagram downward connector

Check minimum number of events None

5768

diagram downward connector

Include endpoints None

5768

diagram downward connector
COPD_EARLY

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 J40-J47
Name in latin Alii morbi obstructivi chronici pulmonum

Summary Statistics

Key figures

All Female Male
Number of individuals 5587 2079 3508
Unadjusted prevalence (%) 1.81 1.20 2.60
Mean age at first event (years) 54.57 52.87 55.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.82 [3.90, 5.97] 1.8e-47 1115
15 years 0.02 3.30 [2.77, 3.93] 7.7e-41 574
5 years 0.01 5.43 [4.58, 6.43] 1.2e-85 275
1 year 0.00 13.16 [10.57, 16.40] <1e-100 127

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: COPD_EARLY – Early onset COPD
GWS hits: 3

Survival analyses between endpoints

Plot

before Early onset COPD
after Early onset COPD

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Early onset COPD