Chronic myeloproliferative disease

CHRONMYELOPRO

chronic myeloproliferative disorder: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D47.1

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 D47.1

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

230

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

230

Check minimum number of events None

230

Include endpoints None

230

CHRONMYELOPRO

Extra metadata

First used in FinnGen datafreeze DF2, additional

Similar endpoints

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List of similar endpoints to Chronic myeloproliferative disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	219	100	119
Unadjusted prevalence (%)	0.07	0.06	0.09
Mean age at first event (years)	62.21	60.51	63.64

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CHRONMYELOPRO – Chronic myeloproliferative disease
GWS hits: 1

Survival analyses between endpoints

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Plot

before Chronic myeloproliferative disease
after Chronic myeloproliferative disease

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Chronic myeloproliferative disease

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