Diffuse large B-cell lymphoma

C3_DLBCL

diffuse large B-cell lymphoma: Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL; see this term) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

HLP_C3_DLBCL

361

Filter registries

Cause of death: ICD-10 C83, C84, C85

Cause of death: ICD-9 200

Cause of death: ICD-8 200

Cancer registry: Topography ICD-O-3 C42|C77

Cancer registry: Morphology ICD-O-3 9680

Cancer registry: Behaviour codes 3

361

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

361

Check minimum number of events None

361

Include endpoints None

361

C3_DLBCL

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF4

Similar endpoints

↥

List of similar endpoints to Diffuse large B-cell lymphoma based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	352	164	188
Unadjusted prevalence (%)	0.11	0.09	0.14
Mean age at first event (years)	65.02	63.41	66.43

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: C3_DLBCL – Diffuse large B-cell lymphoma
GWS hits: 0

Survival analyses between endpoints

↥

Plot

before Diffuse large B-cell lymphoma
after Diffuse large B-cell lymphoma

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Diffuse large B-cell lymphoma

↥