Chronic myeloid leukaemia

C3_CML

obsolete_chronic myeloid leukemia: ['Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

HLP_C3_CML

Filter registries

Cause of death: ICD-10 C92

Cause of death: ICD-9 204

Cause of death: ICD-8 204

Cancer registry: Topography ICD-O-3 C42|C77

Cancer registry: Morphology ICD-O-3 9863

Cancer registry: Behaviour codes 3

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

C3_CML

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF4

Similar endpoints

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List of similar endpoints to Chronic myeloid leukaemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	79	38	41
Unadjusted prevalence (%)	0.03	0.02	0.03
Mean age at first event (years)	57.09	55.03	59.00

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_CML – Chronic myeloid leukaemia
GWS hits:

Survival analyses between endpoints

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Plot

before Chronic myeloid leukaemia
after Chronic myeloid leukaemia

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Table

Loading survival analyses table

Drugs most likely to be purchased after Chronic myeloid leukaemia

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