Chronic lymphocytic leukaemia

C3_CLL

chronic lymphocytic leukemia: B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma (see this term), and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia (see these terms). The clinical course is extremely heterogeneous with survival ranging from a few months to several decades.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions

HLP_C3_CLL

452

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Filter registries

Cause of death: ICD-10 C91
Cause of death: ICD-9 205
Cause of death: ICD-8 205
Cancer registry: Topography ICD-O-3 C42|C77
Cancer registry: Morphology ICD-O-3 9823
Cancer registry: Behaviour codes 3

452

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

452

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Check minimum number of events None

452

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Include endpoints None

452

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C3_CLL

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF4

Summary Statistics

Key figures

All Female Male
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Number of individuals
437 135 302
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Unadjusted prevalence (%)
0.14 0.08 0.22
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Mean age at first event (years)
67.54 67.06 67.76

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Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: C3_CLL – Chronic lymphocytic leukaemia
GWS hits: 0

Survival analyses between endpoints

Plot

before Chronic lymphocytic leukaemia
after Chronic lymphocytic leukaemia

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Drugs most likely to be purchased after Chronic lymphocytic leukaemia