Malignant neoplasm of breast, HER-negative

C3_BREAST_HERNEG

No definition available.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule

Sex only females

180574

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Check conditions

not RX_HERPLUS

172711

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Filter registries

Cause of death: ICD-10 C50
Cause of death: ICD-9 174
Cause of death: ICD-8 174
Cancer registry: Topography ICD-O-3 C50

4943

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

4943

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Check minimum number of events None

4943

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Include endpoints None

4943

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C3_BREAST_HERNEG

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF5

Summary Statistics

Key figures

All Female Male
Number of individuals 4777 4777 -
Unadjusted prevalence (%) 1.55 2.75 -
Mean age at first event (years) 56.97 56.97 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.14 [0.82, 1.57] 4.4e-1 510
15 years 0.00 0.65 [0.48, 0.87] 4.1e-3 195
5 years 0.00 1.89 [1.47, 2.43] 8.0e-7 151
1 year 0.00 4.33 [3.18, 5.90] 1.1e-20 70

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: C3_BREAST_HERNEG – Malignant neoplasm of breast, HER-negative
GWS hits: 7

Survival analyses between endpoints

Plot

before Malignant neoplasm of breast, HER-negative
after Malignant neoplasm of breast, HER-negative

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Drugs most likely to be purchased after Malignant neoplasm of breast, HER-negative