Malignant neoplasm of breast, HER-negative

PheWeb

C3_BREAST_HERNEG

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule

Sex only females

180574

Check conditions

not RX_HERPLUS

172711

Filter registries

Cause of death: ICD-10 C50

Cause of death: ICD-9 174

Cause of death: ICD-8 174

Cancer registry: Topography ICD-O-3 C50

4943

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

4943

Check minimum number of events None

4943

Include endpoints None

4943

C3_BREAST_HERNEG

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF5

Similar endpoints

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List of similar endpoints to Malignant neoplasm of breast, HER-negative based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	4777	4777	-
Unadjusted prevalence (%)	1.55	2.75	-
Mean age at first event (years)	56.97	56.97	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.14 [0.82, 1.57]	4.4e-1	510
15 years	0.00	0.65 [0.48, 0.87]	4.1e-3	195
5 years	0.00	1.89 [1.47, 2.43]	8.0e-7	151
1 year	0.00	4.33 [3.18, 5.90]	1.1e-20	70

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_BREAST_HERNEG – Malignant neoplasm of breast, HER-negative
GWS hits: 7

Survival analyses between endpoints

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Plot

before Malignant neoplasm of breast, HER-negative
after Malignant neoplasm of breast, HER-negative

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Table

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Drugs most likely to be purchased after Malignant neoplasm of breast, HER-negative

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