Malignant neoplasm of breast, HER2-negative

PheWeb

C3_BREAST_HER2NEG

No definition available.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule

Sex only females

Check conditions

not RX_HER2PLUS

Filter registries

Cause of death: ICD-10 C50

Cause of death: ICD-9 174

Cause of death: ICD-8 174

Cancer registry: Topography ICD-O-3 C50

12373

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

12373

Check minimum number of events None

12373

Include endpoints None

12373

C3_BREAST_HER2NEG

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF5

Similar endpoints

↥

List of similar endpoints to Malignant neoplasm of breast, HER2-negative based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	11997	11997	-
Unadjusted prevalence (%)	3.89	6.91	-
Mean age at first event (years)	58.20	58.20	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.58 [1.30, 1.91]	3.4e-6	1031
15 years	0.01	1.05 [0.88, 1.26]	5.7e-1	478
5 years	0.00	2.17 [1.80, 2.61]	2.5e-16	315
1 year	0.00	2.70 [2.05, 3.57]	1.7e-12	79

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: C3_BREAST_HER2NEG – Malignant neoplasm of breast, HER2-negative
GWS hits: 32

Survival analyses between endpoints

↥

Plot

before Malignant neoplasm of breast, HER2-negative
after Malignant neoplasm of breast, HER2-negative

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Malignant neoplasm of breast, HER2-negative

↥