Acute myeloid leukaemia

C3_AML

acute myeloid leukemia: Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

HLP_C3_AML

151

Filter registries

Cause of death: ICD-10 C92

Cause of death: ICD-9 204

Cause of death: ICD-8 204

Cancer registry: Topography ICD-O-3 C42|C77

Cancer registry: Morphology ICD-O-3 9861

Cancer registry: Behaviour codes 3

151

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

151

Check minimum number of events None

151

Include endpoints None

151

C3_AML

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF4

Similar endpoints

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List of similar endpoints to Acute myeloid leukaemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	135	52	83
Unadjusted prevalence (%)	0.04	0.03	0.06
Mean age at first event (years)	61.86	54.14	66.69

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_AML – Acute myeloid leukaemia
GWS hits: 0

Survival analyses between endpoints

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Plot

before Acute myeloid leukaemia
after Acute myeloid leukaemia

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Table

Loading survival analyses table

Drugs most likely to be purchased after Acute myeloid leukaemia

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